Informatics Publishing Limited

P. Muthumani ¹, R. Meera ², Sweetlin ², P. Devi ², B. Kameswari ², B. Eswara Priya ³

Affiliations
1 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Uthangudi, Madurai-625107, IN
2 K.M. College of Pharmacy, Uthangudi, Madurai– 625 107, IN
3 Department of Biotechnology, St. Michael College of Engineering, Sivagangai, TamilNadu, IN

Abstract

Solanum leave Dunal var biegninatum is small shrub is used by the tribals as a medicinal plant. The objective of the present investigation was to study the anti inflammatory, antipyretic and anti fungal activity potential in experimental animal models. The isolated compounds obtained from the chromatography after the extraction completed were used for (SA-I, SA-II, SA-III) these studies. Anti inflammatory potential of isolated compounds (SA-I, SA-II, SA-III) was evaluated by Carrageenan induced paw edema method in rats. Also antipyretic activity was tested on animal models. The studies were conducted on wistar rats of either sex (160-180g). The change in edema volume of the rat hind paw was measured using plethysmometer. The SA-III of isolated compound of Solanum leave dunal inhibited the formation of edema to significant levels in rats treated with carrageenan. At a dose of 100mg/kg orally, the SA-III produced 40.90% inhibition in case of the carrageenan induced edema (p<0.01).

The isolated compounds of Solanum leave Dunal (SA-I, SA-II,SA-III) were also evaluated for antipyretic activity on animals as per Vogel's method. Solanum leave Dunal elicited a dose dependent inhibition of rectal temperature compared with control group. The isolated compound SA-II having maximum antipyretic activity which was compared with standard inhibition at 300mg/kg p.o.

The fungal activity of the isolated compounds (SA-I,SA-II,SA-III) were prepared at various concentration of 1%,2% and 3% solution respectively. In this the compound SA-II(C) having significant antifungal activity compared with other compound against Candida albicans.

The results indicated that the isolated compounds (SA-I,SA-II,SA-III) were active against all the experimentally induced laboratory models of inflammation, pyretic activities and also antifungal activity.

Full Text

     

P. Muthumani ¹, R. Meera ¹, Pratesh ¹, N. Chidambaranathan ¹, P. Devi ¹, B. Kameswari ¹

Affiliations
1 K.M. College of Pharmacy, Uthangudi, Madurai-625107, Tamil Nadu, IN

Abstract

A new series of substituted 4-thiazolidionones were synthesized by cyclization of Schiff’s bases with thiooglycollic acid. The substituted schiff’s bases were synthesized starting from substituted benzoic acid with thionyl chloride in 3 steps. The structures of the synthesized compounds have been established on the basis of physical and spectral data and are screened for anticonvulsant, antibacterial and anti hyperglycemic activities; some of them exhibited significant activity.

Keywords

Substituted 4-Thiazolidinonnes, Anticonvulsant, Anti Hyperglycemic, Anti Bacterial.

Full Text

     

R. Meera ¹, P. Devi ², B. Madhumitha ³, B. Kameswari ³

Affiliations
1 Department of Pharmaceutical Chemistry, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
2 Department of Pharmacognosy, K. M. College of Pharmacy, Madurai-625107 Tamilnadu, IN
3 Department of Biochemistry, K. M. College of Pharmacy, Madurai-625107, Tamilnadu, IN

Abstract

Anti microbial activity of Ether, Acetone Dichloromethane extract and Choloroform extracts and semi synthetic derivatives of Rimelia reticulata were tested against Gram (+) and Gram (-) bacteria strains using zone of inhibition by Agar disc diffusion method.. The bacteria used in test were Gram positive (Staphylococus aureus, Bacillus subtilis and Micrococcus luteus and Gram negative (Escherichia coli, Salmonella typhi and Pseudomonas aureginosa). Moderate antibacterial activity for Ether and Dichloromethane extract, and in Chloroform extract having more than 100% activity and Acetone extract having (90%) activity in Gram (+) organism. In Gram (-) all the extracts having moderate activity (80%). In Semi synthetic derivatives of Rimelia reticulata the Gram (+) and Gram (-) organisms are used. Among the four derivatives 2,4 di nitro hydrazine derivative has more than (100%) activity and 4 nitro phenyl hydrazine, phenyl hydrazine having moderate (80%) activity against Gram (+). In Gram (-) Hydrazine hydrate has shown more than (100% ) and Phenyl hydrazine, 4 nitro phenyl hydrazine having (90%) activity. The standard drug used in this activity is Lincomycin. Based on the current findings it can be concluded that the lichen Rimelia reticulata posses potent antibacterial activity.

Keywords

Rimelia reticulata, Antibacterial Activity, Agar Disc Diffusion Method, Crude Extracts, Semi Synthetic Derivatives.

Full Text

     

R. Badmanaban ¹, C. N. Patel ¹, P. Devi ², R. Meera ², B. Kameswari ², B. Eswarapriya ³

Affiliations
1 Shri Sarvajanik Pharmacy College, Mehasana, North Gujarat, IN
2 K.M. College of Pharmacy, Uthangudi, Madurai, IN
3 St. Michael College of Engineering, Kalayarkovil, Tamilnadu, IN

Abstract

Formulated oil a Siddha formulation was developed using two plant drugs namely Pongamia pinnata seeds and Boerhaavia diffusa ischolar_mains. Preliminary physio chemical screening was performed in both the plants. The wound healing activity was studied with comparison of Sesame oil and Formulated oil by using standard nitro furazone ointment. The methods used were Excision wound model, Incision wound model and Dead space wound model. In excision and incision wound model the formulated oil treated group showed much greater increase in the tensile strength when compared to the control, which was almost similar to that of nitro furazone. In the dead space wound model both the sesame oil and formulated oil produced a significant increase in the wet granuloma tissue weight as well as in the dry weight .Tensile strength was also found to be increased (P<0.001) in both of the oil treated groups.

Keywords

Pongamia pinnata, Boerhaavia diffusa, Sesame Oil, Formulated Oil, Wound Healing Activity.

Full Text